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Meeting program

2nd Global Meeting

Marlo Thomas Center, St. Jude Children's Research Hospital, Memphis, Tennessee, USA · 12–14 April 2024

Held as the Zoltán Patay Scientific Symposium.

Original program (PDF)

Friday 12 April 2024

  1. 08:15–09:00

    Registration and breakfast

  2. 09:00–09:15

    Welcome messages

    Asim Bag and Shivaram Avula

  3. 09:15–10:45

    PanelPatient impact panel. Altered lives: coping with the lifelong impact of posterior fossa syndrome

    Moderated by Elizabeth Hull and Darcy Raches

  4. 10:45–11:30

    KeynoteCoordination of rhythms as a fundamental principle of cerebellar motor and non-motor functions

    Detlef Heck

  5. 11:30–11:45

    Meeting group photo

  6. 12:00–13:00

    Danny Thomas Lecture Series: Cancer Center Director's Round, Charalampos Kalodimos, PhD (optional)

Radiology session

Chairs: Shivaram Avula and Robert Dineen

  1. 13:00–13:05

    Introduction

    Shivaram Avula

  2. 13:05–13:35

    Neuroimaging insights into cerebellar mutism syndrome

    Stu McAfee

  3. 13:35–14:05

    Multicenter validation of pre-operative CMS risk prediction based on radiology

    Shivaram Avula

  4. 14:05–14:15

    AbstractNeuroimaging of post-operative pediatric cerebellar mutism syndrome: a systematic review

    Presenting author: Iris Obdeijn

    Authors: Iris Obdeijn, Kirsten van Baarsen, Shivaram Avula, Sebastian Toescu, Maarten Lequin, Eelco Hoving, Marita Partanen

  5. 14:15–14:25

    AbstractThe neural architecture of word learning: a study in developmental language disorder

    Presenting author: Cheyenne Svaldi

    Authors: Cheyenne Svaldi, Branislava Ćurčić-Blake, Julie Tseng, Kim Vos, Ailene Reinders, Roel Jonkers, Vânia de Aguiar

  6. 14:25–14:35

    AbstractLongitudinal signal changes in the dentate and inferior olivary nuclei in patients with cerebellar mutism syndrome

    Presenting author: Soniya Pinto

    Authors: Soniya Pinto, Matthew Scoggins, Jia Liang, Yimei Li, Raja Khan, Giles Robinson, Paul Klimo, Jr., Samuel McAfee

  7. 14:35–14:45

    AbstractDentato-thalamo-cortical tractography and ambulatory status in the first year of treatment in medulloblastoma patients with and without CMS

    Presenting author: Qing Ji

    Authors: Qing Ji, Raja Khan, Jia Liang, Giles Robinson, Amar Gajjar, Paul Klimo, Jr., Heather Conklin, Darcy Raches, Yimei Li, Samuel S. McAfee, Wilburn E. Reddick, Matthew Scoggins

  8. 14:45–14:55

    AbstractDevelopment and characterization of a pre-clinical model of cerebellar mutism syndrome: in search of mechanistic and therapeutic insight

    Presenting author: Jason Gill

    Authors: Jason Gill, Megan Nguyen, Amanda Brown, Roy V. Sillitoe

  1. 14:55–15:10

    Break

Scoring session: scoring group evidence

Chairs: Andrew Lux and Jason Gill

  1. 15:10–15:40

    Scoring CMS: the journey so far

    Andrew Lux

  2. 15:40–16:40

    Discussion: key questions in scoring and nosology

  3. 16:40–17:10

    Discussion: scoring group

  1. 17:10–18:45

    Abstract poster viewing and welcome reception

Saturday 13 April 2024

  1. 07:30–08:30

    Welcome breakfast and registration

Large-scale studies

Chairs: Giles Robinson and Barry Pizer

  1. 08:30–09:00

    An overview of the St. Jude experience with posterior fossa syndrome and the value of a clinical trial

    Giles Robinson

  2. 09:00–09:30

    Updates on the Nordic European Study of Cerebellar Mutism Syndrome

    René Mathiasen and Jonathan Kjær Grønbæk

  3. 09:30–10:00

    SIOP-MB6 study update

    Kristian Aquilina

  4. 10:00–10:30

    Discussion: future studies

  1. 10:30–10:45

    Break

Surgery section

Chairs: William Gump and Sebastian Toescu

  1. 10:45–10:50

    Introduction

    William Gump

  2. 10:50–11:20

    St. Jude Lecture

    Paul Klimo Jr.

  3. 11:20–11:50

    Towards a PFS surgical consensus statement

    William Gump and Sebastian Toescu

  4. 11:50–12:20

    CMS: where do we go from here? Using AI to open the black box: quantitative analysis of surgical video in clinical trials

    Robert Keating and Daniel Donaho

  5. 12:20–12:30

    AbstractPost-operative posterior fossa syndrome: a retrospective study from a Singapore children's hospital

    Presenting author: Sharon Low

    Authors: Sharon Low, Pui San Koh, Jia Hui Teo, Lee Ping Ng, David Low, Wan Tew Seow, Zhi Min Ng

  6. 12:30–12:40

    AbstractIncidence of postoperative paediatric cerebellar mutism syndrome over a 17-year period with an emphasis on the surgical technique: the Alder Hey experience

    Presenting author: Shivaram Avula

    Authors: Natasha Aziz, Conor Mallucci, Barry Pizer, James Hayden, Dawn Hennigan, Chelsea Harvell, Shivaram Avula

  1. 12:40–13:25

    Lunch

CCAS session

Chairs: Barry Pizer and Alvaro Lassaletta

  1. 13:25–13:55

    CCAS concepts and recent developments

    Jeremy Schmahmann

  2. 13:55–14:55

    Discussion: how to incorporate CCAS into clinical practice and PFS scoring

  1. 14:55–15:10

    Break

Neuropsychology session

Chairs: Darcy Raches and Karin Walsh

  1. 15:10–15:15

    Introduction

    Darcy Raches

  2. 15:15–15:45

    Impact of lesion location on motor and cognitive outcomes in pediatric cerebellar tumor

    Karin Walsh

  3. 15:45–16:15

    Implementing an interdisciplinary approach to coordinated rehabilitation care for patients with posterior fossa syndrome: the role of neuropsychology

    Darcy Raches

  4. 16:15–16:25

    AbstractPsycholinguistic evaluation of narrative language in children with pediatric posterior fossa tumors: an analysis of data of the European Study of CMS

    Presenting author: Ailene Reinders

    Authors: Ailene Reinders, Jonathan Kjær Grønbæk, Ditte Boeg Thomsen, Karen Persson, René Mathiasen, Morten Arnberg Wibroe, Andrea Carai, Bianca Andreozzi, Angela Mastronuzzi, Roel Jonkers, Vânia de Aguiar

  5. 16:25–16:35

    AbstractPredicting neurocognitive outcomes among children experiencing varying degrees of postoperative posterior fossa syndrome

    Presenting author: Heather Conklin

    Authors: Heather Conklin, Darcy Raches, Raja Khan, Jason Ashford, Tong Lin, Arzu Onar-Thomas, Brian Potter, Paul Klimo, Jr., Amar Gajjar, Giles Robinson

  6. 16:35–17:05

    Discussion

  1. 17:05

    Meeting adjourns for the day

  2. 18:15–21:00

    Sunset dinner at Beale Street Landing

Sunday 14 April 2024

  1. 07:30–08:30

    Registration and breakfast

Speech therapy and rehabilitation work group updates

Chairs: Sharyl Samargia-Grivette and Kristin Szymanek

  1. 08:30–08:40

    Work group updates

    Sharyl Samargia-Grivette

  2. 08:40–09:10

    Challenges and opportunities in pediatric acquired motor speech assessment

    Kristin Szymanek and Sharyl Samargia-Grivette

  3. 09:10–09:40

    Randomized controlled trial of aerobic exercise in children with medulloblastoma during radiation therapy

    Robyn Partin

  4. 09:40–09:50

    AbstractAn enriched environment as a key ingredient to active rehabilitation: should rehabilitation focus on the environment during early phases of posterior fossa syndrome? An exploration of current barriers to activity on acute paediatric neurology and oncology wards

    Presenting author: Vicky King

    Authors: Vicky King, Rebecca Knowles

  5. 09:50–10:00

    AbstractParental role modelling as a key ingredient to active rehabilitation: should rehabilitation focus on parents/carers during early phases of posterior fossa syndrome? An exploration of parent and child physical activity levels on an acute paediatric oncology ward

    Presenting author: Rebecca Knowles

    Authors: Rebecca Knowles, Vicky King

  6. 10:00–10:10

    AbstractCognitive Orientation to Occupational Performance (CO-OP) as a potential intervention for children with PFS/CMS

    Presenting author: Vicky King

    Authors: Vicky King

  7. 10:10–10:25

    Break

  8. 10:25–10:35

    AbstractIntensive physiotherapy intervention in children affected by tumors located in posterior cranial fossa

    Presenting author: Daniele Panzeri

    Authors: Daniele Panzeri

  9. 10:35–10:45

    AbstractPediatric posterior cranial fossa tumors: neuro-functional evolution and integrated rehabilitation pathway with development of a specific treatment protocol

    Presenting author: Andrea Carai

    Authors: Riccardo Carbonetti, Francesca Fassari, Maria Simona Musci, Chiara Meliffi, Paolo Dell’ava, Guilia Albino, Andrea DeSalvo, Bianca Andreozzi, Flamina Frascarelli, Antoinella Cacchione, Giada Del Baldo, Angela Mastronuzzi, Andrea Carai

  10. 10:45–10:55

    AbstractZolpidem as a treatment for postoperative cerebellar mutism syndrome (CMS): retrospective study of 16 pediatric patients with posterior fossa tumors

    Presenting author: Alvaro Lassaletta

    Authors: Diannet Quintero, Alvaro Lassaletta, Juan Añón, Felisa Vazquez-Gómez, Jose Luis Moreno-Carrasco, Marta Perez-Somarriba, Serafin Castellano, Zuheya Ippolito-Bastidas, Belen Rivero, Begoña Arce, Carmen De Caceres-Velasco, Susana Cartas

  11. 10:55–11:05

    AbstractAssociation between dysphagia and common clinical symptoms of posterior fossa syndrome in childhood medulloblastoma

    Presenting author: Kristin Szymanek

    Authors: Kristin Szymanek, Tong Lin, Ellen Bursi, Leah Conrad, Erin Howe, Abigail Moore, Giles Robinson, Heather Conklin, Darcy Raches, Arzu Onar-Thomas, Raja Khan

  1. 11:05–12:05

    Final discussion and next steps

    Barry Pizer and Shivaram Avula

  2. 12:05

    Meeting close

Poster presentations

  • Analysis of gamma spectral power differences in CMS

    Authors: Samantha Ertz, Sharyl Samargia-Grivette

  • Analysis of spectral power differences in children with cerebellar mutism syndrome: a controlled EEG study

    Authors: Anna Schmidt, Sharyl Samargia-Grivette

  • Analysis of spectral power differences in children with cerebellar mutism syndrome: a controlled EEG study

    Authors: Amanda Jackson, Sharyl Samargia-Grivette

  • Changes in structural connectivity of thalamocortical networks associated with language, motor control, and somatosensory perception in children with cerebellar mutism syndrome

    Authors: Wilburn E. Reddick, Stu McAfee, Rajikha Raja, John Glass, Asim Bag, Heather Conklin, Amar Gajjar, Giles Robinson, Raja Khan

  • Grey matter correlates of verbal learning in children with developmental language disorder and typically developing children

    Authors: Vânia de Aguiar, Juan-Ignacio Galli, Cheyenne Svaldi, Kim Vos, Ailene Reinders, Annet Kingma, Branislava Ćurčić-Blake, Roel Jonkers

  • Neurologic, neuropsychological, and social outcomes in pediatric patients diagnosed with cerebellar mutism syndrome following posterior fossa tumor resection: a systematic review

    Authors: Margaret Hughes, John Dibello, Callie Fernandez, Kareena Garg, Joseph Paturzo, Jincy Rajan, Suditi Rahematpura, Umayr Shaikh, Supriya Sarvode, Melissa Hudson

  • The psycholinguistic nature of impairments in verb and sentence processing in children treated for posterior fossa tumors and children with developmental language disorders

    Authors: Kim Vos, Ailene Reinders, Cheyenne Svaldi, Branislava Ćurčić-Blake, Annet Kingma, John Maduro, Marita Partanen, Maarten Lequin, Eelco Hoving, Femke Aarsen, Roel Jonkers, Vânia de Aguiar

  • Utilizing CALS serial assessments to inform neurocognitive and interdisciplinary intervention in a patient with posterior fossa syndrome/cerebellar mutism syndrome

    Authors: Bethany Schwandt, Darcy Raches